Ocimum basilicum (OB), also known as sweet basil, is a well known medicinal herb in traditional Chinese medicine preparations. In the present study, extracts and purified components of OB were used to identify possible antiviral activities against DNA viruses (herpes viruses (HSV), adenoviruses (ADV) and hepatitis B virus) and RNA viruses (coxsackievirus B1 (CVB1) and enterovirus 71 (EV71)). 2. The results show that crude aqueous and ethanolic extracts of OB and selected purified components, namely apigenin, linalool and ursolic acid, exhibit a broad spectrum of antiviral activity. Of these compounds, ursolic acid showed the strongest activity against HSV-1 (EC50 = 6.6 mg/L; selectivity index (SI) = 15.2), ADV-8 (EC50 = 4.2 mg/L; SI = 23.8), CVB1 (EC50 = 0.4 mg/L; SI = 251.3) and EV71 (EC50 = 0.5 mg/L; SI = 201), whereas apigenin showed the highest activity against HSV-2 (EC50 = 9.7 mg/L; SI = 6.2), ADV-3 (EC50 = 11.1 mg/L; SI = 5.4), hepatitis B surface antigen (EC50 = 7.1 mg/L; SI = 2.3) and hepatitis B e antigen (EC50 = 12.8 mg/L; SI = 1.3) and linalool showed strongest activity against AVD-II (EC50 = 16.9 mg/L; SI = 10.5). 3. No activity was noted for carvone, cineole, beta-caryophyllene, farnesol, fenchone, geraniol, beta-myrcene and alpha-thujone. 4. The action of ursolic acid against CVB1 and EV71 was found to occur during the infection process and the replication phase. 5. With SI values greater than 200, the potential use of ursolic acid for treating infection with CVB1 and EV71 merits further investigation.
DR EDETANLEN IS A LIFE SAVER AND I CAN ASSURE YOU ABOUT THAT BECAUSE HE GOT MY HUSBAND BACK TO ME. My name is Jennifer and I am here to join the numerous people out here to thank Dr Edetanlen for his help and kind gestures towards me. I had a horrible experience going through heartbreak with my man. He left me and I was devastated and couldn’t find any sought of help to get him back. At some point I was depressed until I ran into pages where people testified about how Dr Edetanlen helped them. I contacted him and he never hesitated to help me as well. Not only did I get my man back after 48 hours, the love and happiness has also been restored better than ever. Dr Edetanlen is an amazing personality and I can’t thank him enough for his selfless services towards humanity. Contact him now via email:firstname.lastname@example.org or WhatsApp +2349153512788 https://www.facebook.com/profile.php?id=100092647912835
Reconnect with your ex lover with the help Lord Zakuza spell. Email him on lordzakuza7 @gmail. com
I was browsing the Internet searching for help when I came across a testimony shared by someone on how she was cured from Herpes Disease. I quickly contacted him to get the cure also and today i am now free from the Virus, robinsonbuckler [@yahoo [.] com.. …………..