Anxiolytic effects of a Valerian extract is based on valerenic acid

Valerian is commonly used for the treatment of insomnia and anxiety. Valerian extracts allosterically modulate GABA-A receptors and induced an anxiolytic activity. This activity is closely related to valerenic acid. In the present experiments it was investigated whether acetoxy valerenic acid may interfere with the anxiolytic action of valerenic acid. Situational anxiety was measured using male CD-1 mice in the elevated plus maze test after oral administration of the test substances. In addition the body core temperature was measured. For the 3H-GABA binding assay dissected tissue from frontal cortex of male RjHan:WI rats were used. Statistical evaluation was performed by means of the non-parametric Kruskal-Wallies H-test, followed by the two-tailed Mann-Whitney U-test. Adding of acetoxy valerenic acid abolished the anxiolytic action of valerenic acid. There was no effect on body core temperature. Moreover, the valerian extract did not show any affinity to benzodiazepine binding sites. The determining compound for the observed anxiolytic effect of the valerian extract is its content of valerenic acid.

Click to read more

2149 comments

juneqc1

juneqc1

Enjoy our scandal amateur galleries that looks incredibly dirty
http://bloglag.com/?mckayla
emperor new school porn list porn site free british amateur porn tgp free porn true blood gay college student porn pics

BqtQM

BqtQM

help for writing college admission essay paper route writing on the wall lyrics best admissions essay help

eileensi16

eileensi16

Hot galleries, thousands new daily.
http://swingers.porn.north.hartland.jsutandy.com/?breana
first time czech gay porn hot gay porn star classy bbw porn hentai porn vid amatuer mexican porn

tanishazt2

tanishazt2

Dirty Porn Photos, daily updated galleries
http://porninoldwestphilomath.jsutandy.com/?madisyn
public voyeurism porn yahoo truly free porn tyras porn free hd porn trailers free gat porn movies

BdpLL

BdpLL

what is the best essay writing service with ggod price college personal essay what my military service meant to me essay

ZxvRA

ZxvRA

z essay service review professional essay writing service when did the essay writing service trend begin?

michealjm11

michealjm11

Sexy photo galleries, daily updated pics
http://webcam.porn.williston.highlands.alexysexy.com/?joselyn
online porn viedeos underground porn magazines teen chrisymas porn free online simpsons porn games simposns porn video tubes

rosariody4

rosariody4

My new hot project|enjoy new website
http://pornteenbigdick.tasley.hoterika.com/?karissa
you porn animal sex taylor bow girlfriend porn site bree olsons porn kate gibson porn gonzo porn thumbnails

kirstenik18

kirstenik18

Young Heaven – Naked Teens & Young Porn Pictures
http://atglen.sexjanet.com/?armani
free video porn vagina flat chested shiny porn free streaming german porn gay porn man free tube animal porn

NylVY

NylVY

applying to cia essay help phd comics paper writing i would be forever grateful if you can help me cut an essay down

pollyry18

pollyry18

Nude Sex Pics, Sexy Naked Women, Hot Girls Porn
http://highlandheightsfreepornballet.adablog69.com/?eliza
khmai porn porn star peach porn vulcan free monster cock porn vids juli aston porn clips

RerEY

RerEY

college application essay review service writing college essays sue essay writing service

kimrj3

kimrj3

New sexy website is available on the web
http://cowenbedporn.gigixo.com/?marissa
lezbo porn tour diamond exotic blonde teen porn free alien women porn forced sex in public porn videos lesbian full length porn videos

tommiest11

tommiest11

Dirty Porn Photos, daily updated galleries
http://asianogasimporn.donaldson.moesexy.com/?beatriz
porn benfranklin amateur home made big tit porn three girls one man porn porn movies zhi ling pokemon porn movie

DbePK

DbePK

college entrance exam essay help news paper writer how does the tone of this essay help understand his dillemma

sharondp11

sharondp11

Enjoy our scandal amateur galleries that looks incredibly dirty
http://viapaxtonporn.blackwater.alexysexy.com/?nicole
porn star dancer sabrina crossdresser sissy porn clips vanessa hudgens look alike porn free porn webcams greedy mothers and son porn

YuhQM

YuhQM

community service essay examlpes best custom essay writing service recommend3ed proofreading essay service

mathewvl2

mathewvl2

Sexy photo galleries, daily updated collections
http://uvachicksporn.dewitt.gigixo.com/?rayna
best no join porn ivy porn lindsey lohan lesbian porn worlds fattest gay porn star bootycall porn comic

priscillaku11

priscillaku11

Hot galleries, thousands new daily.
http://swingers.porn.hotnatalia.com/?tyler
free mature swingers porn movie clips categorized porn vintage movies british mom porn disgusting free porn videos amateurs who love porn

nonaie4

nonaie4

Daily updated super sexy photo galleries
http://hentai.hotnatalia.com/?dayana
jack lawrence porn star ebony girl porn porn fb gag factor porn teen porn saqmple vids

BwlMN

BwlMN

essay help why is it sometimes necessary to take a risk best paper for fountain pen writing 8. in a well-structured essay, each topic sentence should help to explain or support

petrapw11

petrapw11

New hot project galleries, daily updates
http://kinloch.officewomenporn.danexxx.com/?madeline
busty coeds porn videos really free porn clips cowgirl porn video sensi black british porn stud face hugger porn

LsvTZ

LsvTZ

site:the-end-time.blogspot.com (essay|writing|personal|service|cheap) top rated essay writing service sample essay writing service

amiefg60

amiefg60

Free Porn Pictures and Best HD Sex Photos
http://oldjeffersonporn989.alexysexy.com/?devin
free porn vids youporn brandy cartoon porn gratis online porn oldest women videoo porn gay porn thumb

constancejd16

constancejd16

Sexy teen photo galleries
http://cumshot.bedford.miyuhot.com/?aylin
girl schools porn dead or alive anime porn porn trailers video squirting pissing anal porn ashley upright porn

joyfy2

joyfy2

New hot project galleries, daily updates
http://tucker.galerisporn.sexjanet.com/?wendy
ds lite porn vintage spanking porn violent porn movie thumbs fuck blood porn porn forum rapdishare

carlyzy69

carlyzy69

New sexy website is available on the web
http://callensburg.miaxxx.com/?tara
mature panites porn review of free porn tubes black girth porn vica porn angel baby porn star

deannlx18

deannlx18

Big Ass Photos – Free Huge Butt Porn, Big Booty Pics
http://blowjob.kanakox.com/?jessie
jodi breeze porn actor girls kissing videos porn free cg 3d porn amature lesbians porn sex scandal porn

elviahi2

elviahi2

Daily updated super sexy photo galleries
http://snakepornkilmarnock.danexxx.com/?jaelyn
treasury employee porn pinks world of porn hot virgin porn 2010 courage the cowardly dog porn scooby doo big tit porn

shaunahn2

shaunahn2

Dirty Porn Photos, daily updatedr galleries
http://transgender.porn.moesexy.com/?tatiana
innocent porn tube full length hentai comic porn videos femdom prostat hand job porn tube adult porn teen real c porn

CvjFY

CvjFY

herbal viagra green box sildenafil goodrx super viagra

patsysy2

patsysy2

Browse over 500 000 of the best porn galleries, daily updated collections
http://interractial.porn.jsutandy.com/?kennedi
anal bloopers porn porn satr site stevenage porn star watch full length gay porn free sifi porn sex 3d

lorettafx69

lorettafx69

New sexy website is available on the web
http://lake.worthgraveyfreeporn.kanakox.com/?aaliyah
girl fucking big cock porn nude indian gay porn german deepthroat porn daughter comes home early porn best free porn web site facials

IrvFV

IrvFV

kernel essay help dissertation writing help services to help you write your college essay

jamesbx1

jamesbx1

Free Porn Galleries – Hot Sex Pictures
http://towerlakes.redheadteenporn.hotnatalia.com/?tatum
porn actress interveiw letters page porn magazines sara jay free porn new zealand porn moives lori anderson porn site

annmariesh2

annmariesh2

Nude Sex Pics, Sexy Naked Women, Hot Girls Porn
http://fakeclebepornarlington.jsutandy.com/?madilyn
jimi hendrix porn amatuer african porn part 1 youngleafs porn free mirjam porn movies james bond porn video

VwbJT

VwbJT

natural viagra recipe viagra 100 mg buy generic 100mg viagra online

PruKA

PruKA

help to make compare and contrast essay dissertation writing help essay on my desire to help others

elsadg4

elsadg4

Enjoy daily galleries
http://kenai.alypics.com/?morgan
milf porn mom xxx anal iran hairy porn persian porn sex movies hypnotize girl porn cyril cole porn

gabrieljo3

gabrieljo3

New super hot photo galleries, daily updated collections
http://cottontownmypornbucket.topanasex.com/?margarita
teenboy porn tgp big nipple porn free expect porn italian nun porn sandra brown porn star

ZpdJU

ZpdJU

female viagra cvs viagra for sale sildenafil cvs

MtmTA

MtmTA

linked in essay help writing a masters dissertation with the help of my local librarian i wrote the bes essay

ramonadg11

ramonadg11

Enjoy daily galleries
http://yuba.freeporntoread.hoterika.com/?deanna
porn star poway high online adult guide porn free porn xxcx vidieos shanti porn porn in ipod

jodyrj16

jodyrj16

Hot galleries, daily updated collections
http://lyons.hardcore.porn.adablog69.com/?ashtyn
porn amateur homemade free porn by snail mail porn site for thirteen year olds mature mom amateur porn image photo secretary porn thumbs

darrenmk11

darrenmk11

Free Porn Pictures and Best HD Sex Photos
http://pornindianbabe.monongahela.kanakox.com/?angelica
whore next doo porn barn house porn fiind porn partys gone wild porn amaturs porn

markcc4

markcc4

Young Heaven – Naked Teens & Young Porn Pictures
http://pornsexlatinapolvadera.hoterika.com/?zoey
sexy adulteress porn soft core porn hq free anime porn samples free3 porn videos free porn pic downloader

maryellengw1

maryellengw1

Sexy pictures each day
http://warrentonvaporn.navesink.sexjanet.com/?keeley
islam free sex porn twilight free milf porn picture galleries most popular mature porn stars porn wet pussys videos make money with web cam porn

enriqueaw3

enriqueaw3

Best Nude Playmates & Centerfolds, Beautiful galleries daily updates
http://lawrence.antasyporn.alypics.com/?jolie
free watersports porn movies collin farrel porn adult games not porn british heather porn japan cartoon porn

reneul60

reneul60

Hot galleries, daily updated collections
http://miamatureporn.tieton.hotnatalia.com/?kassandra
poirn smal boy porn milfs that swallow cum outdoor masterbation porn pics hamster porn vid porn mouth cum compilation

pattixb2

pattixb2

Best Nude Playmates & Centerfolds, Beautiful galleries daily updates
http://empirefatfemaleporn.alexysexy.com/?aiyana
amatuar spy porn free amatur fetish porn ashton galleries porn viet teen porn video ukraine porn tube

Leave a comment