Gastroprotective and antiulcer activity of mixture of Symplocos racemosa bark and Asarum europaeum root

The aim of present study is to evaluate the gastric antisecretory and antiulcer activity of mixture of Symplocos racemosa bark and Asarum europaeum root. The mixture of Symplocos racemosa bark and Asarum europaeum root, were dried in shade and powdered coarsely and extraction was done according to standard procedure. The aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root was used in the pylorus ligated, aspirin and ethanolic induced ulcer models. The aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root showed significant anti-secretory activity as evidenced by decreased pepsin secretion, gastric juice volume and acid output in pylorus ligated rats. Pretreatment with of mixture of Symplocos racemosa bark and Asarum europaeum root extract provided significant protection against the peptic ulceration caused by aspirin and ethanolic treated rats. It showed significant gastroprotective effects on the stomach wall in aspirin and ethanol treated rats by increasing the gastric wall mucous. The present findings demonstrate that aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcer.

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