Protective effect of Aloe vera gel on the permeability transition pore in the inner membrane of rat liver mitochondria in vitro.

Aloe vera is a perennial drought resisting, succulent plant belonging to the zanthorrhoeaceae family which historically has been used for a variety of medicinal purposes. This study seeks to determine the effect of varying concentrations of Aloe vera gel (50, 100, 150, 250, and 350 µg/ml) on mitochondrial permeability transition pore (MPTP) in rat liver mitochondria (RLM) (in vitro).These findings indicate that Aloe vera gel modulates the mitochondrial pore opening by further increasing the effect of calcium. This effect is needed in situations that requires tissue wastage such as in cancer treatment.

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